Dear GANM community,
In this week’s edition of the GANM Library Research Brief we bring to you three articles centering around the COVID-19 vaccine in pregnant and lactating women, socioeconomic status and fetal brain development, and hypertension in pregnant women/childbearing individuals.
Gray, K. J., Bordt, E. A., Atyeo, C., Deriso, E., Akinwunmi, B., Young, N., Medina Baez, A., Shook, L. L., Cvrk, D., James, K., De Guzman, R., Brigida, S., Diouf, K., Goldfarb, I., Bebell, L. M., Yonker, L. M., Fasano, A., Rabi, S. A., Elovitz, M. A., Alter, G., & Edlow, A. G. (2021). COVID-19 vaccine response in pregnant and lactating women: a cohort study. American Journal of Obstetrics and Gynecology. doi: https:// doi.org/10.1016/j.ajog.2021.03.023.
Our first article, published in the American Journal of Obstetrics and Gynecology (AJOG) seeks to evaluate the immunogenicity of the COVID-19 mRNA vaccine in pregnant and lactating women. In this cohort study 131 pregnant subjects received the vaccine, all of which had vaccine-induced antibodies that were equivalent to non-pregnant women. The study concluded that the vaccine created a robust humoral immune response in childbearing women.
Lu, Y., Kapse, K., Andersen, N., Quistorff, J., Lopez C., Fry, A., Cheng, J., Andescavage, N., Wu, Y., Espinosa, K., Vezina, G., du Plessis, A., & Limperopoulos, C. (2021). Association between socioeconomic status and in utero fetal brain development. JAMA Network Open, 4(3):e213526. doi:10.1001/jamanetworkopen.2021.3526
In a cohort study of 144 pregnant individuals’, researchers recently discovered that lower socioeconomic status (SES) was associated with overall fetal brain tissue volume. This study found that the altered brain morphology was in direct relation to low SES and used MRI to quantify these results. The results show that more support should be available to those of lower socioeconomic to decrease this disparity and improve outcomes and quality of life.
Bello, N. A., Zhou, H., Cheetham, T. C., Miller, E., Getahun, D. T., Fasset, M. J., & Reynolds, K. (2021). Prevalence of hypertension among pregnant women when using the 2017 American College of Cardiology/American Heart Association blood pressure guidelines and association with maternal and fetal outcomes. JAMA Network Open, 4(3):e213808. doi:10.1001/jamanetworkopen.2021.3808
Does the prevalence of hypertension among pregnant women change when applying the 2017 AHA blood pressure guidelines compared to the ACOG guidelines? This is the questions recently asked in a study by Bello and colleagues. In a cohort study of 137,389 participants the prevalence increased from approximately 10% to 28%. The implications for these results have the ability to detect hypertensive disorders such as preeclampsia among childbearing individuals in addition to fetal and/or neonatal adverse events and outcomes.