Dear GANM community,
In this week’s edition of the GANM Library Research Brief we turn our attention to three articles focusing on HIV and health disparities, kidney injuries in children, and COVID-19.
Each article discusses important concepts of health such as knowledge, socioeconomic status, and many more.
Myers, S. R., Glaser, N. S., Trainor, J. L., & Kuppermann, N. (2021). Frequency and risk factors of acute kidney injury during diabetic ketoacidosis in children and association with neurocognitive outcomes. JAMA Network Open. 3(12):e2025481. doi:10.1001/jamanetworkopen.2020.25481
What are the mechanisms and risk factors associated with acute kidney injuries during pediatric diabetic ketoacidosis (DKA)? This is the question research recently asked in a study published in JAMA. In a cohort of 1,369 DKA pediatric patients acute kidney injuries occurred 43% of the time. These patients were also at an increased risk for severe acidosis and circulatory volume depletion. In addition, these patients were more likely to have neurocognitive impairments during DKA and lower IQs during follow up.
Yang, F., Li, Z., Subramianian, S. V., Lu, C. & Lu, C. (2021). Assessment of knowledge of HIV/AIDS and association with socioeconomic disparities among young women in low- and middle-income countries, 2003 to 2018. JAMA Network Open. 4(1):e2035000. doi:10.1001/jamanetworkopen.2020.35000
How has knowledge of HIV/AIDS in addition to socioeconomic status changed in low- and middle-income countries between the years of 2003 and 2018? In this cross-sectional study with 282,757 participants in 51 countries approximately 1/3 reported having knowledge about HIV/AIDS. While there was a significant increase in knowledge in 24 countries these data suggest that further HIV/AIDS prevention educational campaigns need to be initiated.
Bravata, D. M., Perkins, A. J., Myers, LJ., & Keyhani, S. (2021). Association of intensive care unit patient load and demand with mortality rates in us department of veteran’s affairs hospitals during the COVID-19 pandemic. JAMA Network Open, 4(1):e2034266. doi:10.1001/jamanetworkopen.2020.34266
In this recent article published in JAMA researchers asked the following question: Is greater coronavirus disease 2019 (COVID-19) intensive care unit (ICU) strain associated with increased COVID-19 mortality? Findings suggested that out of 8,516 patients diagnosed with COVID-19, 88 were admitted to VA hospitals and strains on critical care capacity were associated with increased mortality. This supports an effort to consider interventions to reduce ICU demand and improve survival overall.